J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

Abstract J-aggregation is an efficient strategy for the development of fluorescent imaging agents in second near-infrared window. However, design J-aggregates challenging due to lack suitable dyes. Herein, we report meso -[2.2]paracyclophanyl-3,5-bis- N , -dimethylaminostyrl BODIPY (PCP-BDP2) as example dye with induced fluorescence. PCP-BDP2 shows emission maximum at 1010 nm state. Mechanism studies reveal that steric and conjugation effect PCP group on play key roles behavior photophysical properties tuning. Notably, can be utilized lymph node fluorescence-guided surgery nude mouse, which demonstrates their potential clinical application. This study alternate platform developing agents.